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The capture flops in the EWC typically run on S32KCLK, and therefore S32CLK is expected to be always on. If however, the system designer replaces the interrupt capture flops in the EWC with latches, the EWC does not require S32KCLK.
The wakeup request must be generated from the capture flops without any other clock running, other than S32KCLK, if flops are used instead of latches. All other flops in the EWCs are expected to run on SYSCLK or FCLK depending on which core it is associated with.